Dihexa

Dihexa (PNB-0408) is a synthetic peptide derived from angiotensin IV, developed by researchers at Washington State University under Dr. John Hoges.

Mechanism of Action
Dihexa is a potent agonist of the c-Met receptor — the primary receptor for hepatocyte growth factor (HGF). Activation of this pathway stimulates new synapse formation (synaptogenesis), increases synaptic density, and promotes neuroplasticity. Preliminary research data suggests activity approximately 10,000-fold greater than BDNF at comparable molar concentrations.

Research Data
Animal model studies demonstrated significant improvements in cognitive function, spatial memory, and learning. The peptide showed sustained effects even after single administration. Studies on neurodegenerative pathology models suggest potential for cognitive function restoration.

Physicochemical Properties
Soluble in DMSO and acidified aqueous solutions. Recommended storage at −20°C in lyophilized form. Protect from direct sunlight and moisture.